A while ago I put together a little library that determines internal rate of return for a series of cash flows. This is a problem in the accounting domain and was prompted by the inadequacy of the features in excel. I did not want to haul the whole of excel into the application I was building. I tend to stay clear of Interop if I can help it.
Well the short of it is that the lib averages 1.5 downloads per day. Not much for 15 mins work, but this has led me into thinking that perhaps there is a larger market for reusable math/scientific libraries. How about a DNA sequencing lib?